The European Medicines Agency (EMA) has started a review of adrenaline auto-injectors, which are used as first-aid treatment of anaphylaxis (severe allergic reactions) prior to calling for emergency medical assistance.
This review was requested by the UK medicines agency, the MHRA, following a national review of all adrenaline auto-injector products approved in the UK. Although the product information of adrenaline auto-injectors states that the devices deliver adrenaline into a muscle, the UK review concluded that there is no robust evidence that this is the case for all patients. Depending on individual factors such as skin-to-muscle depth, adrenaline may instead be injected under the skin (but not into a muscle), which may result in a different absorption profile.
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